Response to cobos

Osteoarthritis, Celebrex, and Ibuprofen

Osteoarthritis is a form of arthritis that mainly develops due to wear and tear on the cartilage found in bone joints and results in joint pains, especially for the joints that move the most such as the knees, fingers, and arms. According to Sharma (2021), the main symptoms of Osteoarthritis include pain and stiffness in the specified joint which results in limited movements for the patient due to the pain that they experience. Age progression resulting in wear and tear due to joint use is the main cause of Osteoarthritis and reversal of joint cartilage after wear is impossible which leaves the management of symptoms as the main form of treatment for Osteoarthritis.

First-Line Therapy for Osteoarthritis

The lack of treatment for Osteoarthritis results in symptom management as the main form of treatment from which NSAIDs are the main form of medicine for the patient since pain is the most prevalent and presents symptoms requiring management. Arden et al. (2021) acknowledge that topical and oral NSAIDs are the first line of treatment for the patient with dependence on the degree of pain that they are experiencing with the progression of their Osteoarthritis. Bariguian et al. (2020) identify that diclofenac is the best form of NSAID to be applied as a first-line treatment since it is effective and well-tolerated by many patients. The main mechanism of action for NSAIDs is pain-relieving through the inhibition of the enzyme cyclooxygenase which reduces the detection of the pain stimuli by the pain (Ghlichloo & Gerriets, 2019). Thus, the application of NSAIDs results in the patient having less feeling of their pain symptoms while also having their quality of life slightly elevated. 

Celecoxib Benefits and Risks

Celecoxib is also an NSAID class of medication that assists in the management of pain and can be applied to patients with Osteoarthritis for their joint pains in order to relieve their pains and try to enhance Osteoarthritis management. According to Huang et al. (2021), celecoxib was found to be more effective and efficient in the reduction of pain when compared to diclofenac for patients with knee Osteoarthritis. The first benefit that the patient will gain through the use of celecoxib will be the elevation of their pain symptoms more effectively and efficiently as compared to other forms of NSAIDs, especially after the failure of ibuprofen. Pu et al. (2021) acknowledge that better analgesic efficacy and higher patient satisfaction levels are also experienced with the application of Celecoxib for pain management. Solomon et al. (2018) identify that the use of Celecoxib in the right dosage resulted in a lower risk for cardiovascular events, and gastrointestinal and also renal adverse events. Shin (2018) also points out that an increase in cardiovascular risk when using Celecoxib was found to only increase with a