o Prepare:

  • Reflect on the four peer-reviewed articles you selected in Module 2 and the four systematic reviews (or other filtered high- level evidence) you selected in Module 3.
  • Reflect on the four peer-reviewed articles you selected in Module 2 and analyzed in Module 3.
  • Review and download the Critical Appraisal Tool Worksheet Template provided in the Resources.

The Assignment (Evidence-Based Project)

Part 3A: Critical Appraisal of Research

Conduct a critical appraisal of the four peer-reviewed articles you selected by completing the Evaluation Table within the Critical Appraisal Tool Worksheet Template. Choose a total of four peer- reviewed articles that you selected related to your clinical topic of interest in Module 2 and Module 3.

Note: You can choose any combination of articles from Modules 2 and 3 for your Critical Appraisal. For example, you may choose two unfiltered research articles from Module 2 and two filtered research articles (systematic reviews) from Module 3 or one article from Module 2 and three articles from Module 3. You can choose any combination of articles from the prior Module Assignments as long as both modules and types of studies are represented.

Part 3B: Critical Appraisal of Research

Based on your appraisal, in a 1-2-page critical appraisal, suggest a best practice that emerges from the research you reviewed. Briefly explain the best practice, justifying your proposal with APA citations of the research.


Evaluation Table

Use this document to complete the
evaluation table
requirement of the Module 4 Assessment, Evidence-Based Project, Part 4A: Critical Appraisal of Research



Essentials of Evidence-Based Practice

Francis Mercado

Dr. Linda Johanson

Matrix Worksheet Template

Use this document to complete Part 2 of the Module 2 Assessment,
Evidence-Based Project, Part 1: An Introduction to Clinical Inquiry and Part 2: Research Methodologies

Full APA formatted citation of selected article.

Article #1

Article #2

Article #3

Article #4

Evidence Level *

(I, II, or III)

Conceptual Framework

Describe the theoretical basis for the study (If there is not one mentioned in the article, say that here).**


Describe the design and how the study was carried out (In detail, including inclusion/exclusion criteria).


The number and characteristics of

patients, attrition rate, etc.

Major Variables Studied

List and define dependent and independent variables


Identify primary statistics used to answer clinical questions (You need to list the actual tests done).

Data Analysis Statistical or

Qualitative findings

(You need to enter the actual numbers determined by the statistical tests or qualitative data).

Findings and Recommendations

General findings and recommendations of the research

Appraisal and Study Quality

Describe the general worth of this research to practice.

What are the strengths and limitations of study?

What are the risks associated with implementation of the suggested practices or processes detailed in the research?

What is the feasibility of use in your practice?

Key findings

of the selected article

Article #1

Article #2

Article #3

Article #4

Steffens, E., Spriet, I., Van Eldere, J., & Schuermans, A. (2019). Compliance with evidence-based guidelines for the prevention of central line-associated bloodstream infections in a Belgian home care setting: An observational study. American Journal of Infection Control, 47(6), 723-725. 

Ting, J. Y., Goh, V. S., & Osiovich, H. (2013). Reduction of central line-associated bloodstream infection rates in a neonatal intensive care unit after implementation of a multidisciplinary evidence-based quality improvement collaborative: A four-year surveillance. Canadian Journal of Infectious Diseases and Medical Microbiology, 24(4), 185-190. 

Conley, S. (2016). Central line-associated bloodstream infection prevention: Standardizing practice focused on evidence-based guidelines. Clinical Journal of Oncology Nursing, 20(1), 23-26. 

De Miranda Costa, M., Santana, H., Saturno Hernandez, P., Carvalho, A., & Da Silva Gama, Z. (2020). Results of a national system-wide quality improvement initiative for the implementation of evidence-based infection prevention practices in Brazilian hospitals. Journal of Hospital Infection, 105(1), 24-34. 

you chose this article and/or
how it relates
to the clinical issue of interest (include a brief
explanation of the ethics
of research related to your clinical issue of intere

Central Line-associated Bloodstream Infections.

Walden University

Dr. Linda Johanson

Francis Mercado


Identification and description of the clinical issue.

The clinical issue or problem identified for my study is the central line bloodstream infections (CLABSI)

Central line bloodstream infections(CLABSI) is a health condition that affects many people.

It occurs when pathogens such as bacteria and other germs invade the patients central line after which they get into the bloodstream.

CLABSI related infections are often serious but they can be successfully managed through appropriate treatment approaches.

Femoral central venous catheters and internal jugular along with subclavian central lines have high risk of getting infected.

As per the survey conducted in 2019 about the central line bloodstream infections, it was found that the infection ratio for the said infections was 0.8 per 1000 central line days. This means that over 250000 people across the world bloodstream infections occur yearly and most of them are associated with the presence of intravascular devices.


Identification and description of the clinical issue.

Risk factors for Central Line-associated Bloodstream Infections (CLABSI)

presence of gastrostomy tube.

 ICU placement of central venous catheter.


Antibiotic therapy(Steffens et al., 2019,).

Poor nutrition;

Multiple invasive procedures.

 nonoperative cardiovascular disease.

Central line bloodstream infection is associated with numerous predisposing risk factors. From healthcare stats, it can be said that central line catheters are the common causes of health callings linked to CLABSI. However there are many other risk factors that predispose patients to contracting or developing central line bloodstream infections. Contamination may occur within the central line and this may cause central line related illness. Such contamination include; non interact dressing, contaminated infusion, central venous access devices as well as patient’s skin flora.


How to develop PICOT question for CLABSI

By analyzing the major components of PICOT, that is P-population, patients, or problem at hand, I-interventions required to solve the issue, C- control or alternative interventions to be compared, O-outcome or the objective to be achieved and T-time framework required to achieve desired outcome(Steffens et al., 2019).

This will help formulate questions such as;

Who and what is the issues that need to be addressed?

What is the proposed intervention and actions to remedy the issue?

What is desired outcome?

How much time is required to realized anticipated resul